Hmm...Let's try this a different way.
A lady out in Colorado thinks people who live life too cautiously are missing a lot of the excitement, and joy, one can get out of life.
This part of the clue is a sort of paraphrase of the message contained in the subjects siggy
She's also convinced that having just 4 ? equals 1 ??
This part of the clue is a veiled reference to the subjects screen name.
The only bearing Colorado has on the clue is that she lists Colorado as her location. Of course lots of members live in Colorado, so that isn't much help to you.
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